The Lloyd Lab

Welcome to the Lloyd Lab at the Johns Hopkins School of Medicine!

Principal Investigator

Thomas Lloyd, M.D., Ph.D

Associate Professor of Neurology and Neuroscience

Dr. Thomas Lloyd specializes in neuromuscular disorders in adults, with a particular interest in neurogenetics and motor neuron diseases including amyotrophic lateral sclerosis (ALS), motor neuropathies, and muscle diseases such as Inclusion Body Myositis (IBM). His research interests include understanding the mechanisms of motor neuron degeneration using simple genetic model systems. Current investigations focus on the role of genes that regulate transport of organelles and survival signals along motor nerve axons. In the lab, he is developing genetic and pharmacologic screens to identify novel drug targets for motor neuron diseases. Tom received his M.D. and Ph.D. from Baylor College of Medicine in Houston, Texas. He then came to Johns Hopkins Hospital for residency training in Neurology, after which he completed a fellowship in Neuromuscular Medicine.

Post-Doctoral Fellows

Kai Ruan, Ph.D

Kai received his BS degree in life science at his hometown, Xi’an, China. Later, he went to Xiamen University to obtain his MS degree in Cancer Biology. In 2009, Kai attended the University of Miami Miller School of Medicine where he received his PhD degree studying the post-transcriptional regulation of a neuronal maintenance factor, NMNAT in Drosophila with Dr. Grace Zhai. He joined the Lloyd Lab in March 2016 and interested in dissecting the potential molecular mechanisms underlying neuronal maintenance and neuroprotection in neurodegenerative diseases. He enjoys swimming, travelling with friends, and playing video games.

Hyun Sung, Ph.D

Hyun is from Seoul, South Korea. He received his BS and MS in life sciences at Hanyang University, and received his PhD in neuroscience and physiology at Purdue University. During his PhD, he studied axonal transport of mitochondria and organelle quality control with Dr. Peter Hollenbeck. At the Lloyd lab, he is interested in the role of axonal transport with organelle dynamics in motor neuropathies, such as ALS and CMT.

Sandeep Dubey, Ph.D

Sandeep has received his PhD degree in the laboratory of Prof. Madhu Tapadia at Banaras Hindu University, India, where he worked on the role of Hippo pathway and nucleocytoplasmic transport in PolyQ-meditated neurodegeneration using genetic and cell biology approaches in Drosophila. In Lloyd lab, he is interested to stufy how C9orf72 disrupts the nucleocytoplasmic transport machinery by using expansion microscopy to perform super-resolution imaging of the nuclear pore complex.

Sunyuan Zhang, Ph.D

Sunyuan Zhang received her Bachelor degree in Life Sciences from Peking University, China in 2014. Later she finished her PhD degree in Biochemistry and Molecular Biology in the University of Melbourne, Australia in 2018. She joined Iloyd lab in Septermber 2019 and became part of the ALS disease mechanism team with main focus on RNA metabolism. In her free time, she enjoys reading, cooking, badminton, running, and hiking.

Graduate Students

Kyla Britson

Graduate student, Cellular Molecular Medicine graduate program. Her thesis project is on pathogenesis and biomarker development for IBM. Awarded travel fellowship to attend Global Conference on Myositis in Berlin, Germany where she was awarded best overall oral presentation (out of 33 eligible speakers) and a “speed funding” 15,000 Euro award to support her research (funded by MyositisUK).

Kyla Britson graduated from the University of Minnesota-Twin Cities in 2013 with a Bachelor of Science in Genetics, Cell Biology, and Development. It was her interest in cell and developmental biology that initially drew her to Johns Hopkins to work as a technician in Dr. Deborah Andrew’s laboratory studying the cellular dynamics of Drosophila salivary gland development. In 2015, she matriculated in the Cellular and Molecular Medicine graduate program, and joined the Lloyd lab shortly thereafter to pursue a thesis exploring the cellular mechanisms underlying Inclusion Body Myositis. In her free time, Kyla enjoys rock climbing, hiking, and playing violin in the Hunt Valley Symphony.

Kirstin Maulding

Kirstin Maulding graduated from Texas A&M University in 2016 with a BS in Molecular and Cell Biology and minors in Genetics and Neuroscience. Her interest in neuroscience and neurodegenerative disease peaked her interest in the Cellular and Molecular Medicine program here at Johns Hopkins. She joined the Lloyd lab and is now studying the underlying mechanisms that cause neurodegeneration, including aberrant signaling pathways and disruption of the nuclear pore. In her free time, she enjoys backpacking, reading, and hanging out with her cats.

Laboratory Manager

Andrew Cheng

Andrew Cheng joined the Lloyd Lab in July of 2017 as a research technologist and lab manager. Prior to joining the lab, Andrew graduated from the University of Maryland, College Park where he studied bioengineering with interests in biomedical devices and electronics. In lab, Andrew studies the role of the Dynactin complex in neurodegenerative diseases such as HMN, ALS, and Perry Syndrome. In his spare time, he enjoys physical activities, such as weightlifting, tennis, and ultimate frisbee, as well as the occasional movie or video game night.

Undergraduate Research Assistants

Dominick Rich

Dominick is a junior at Johns Hopkins University studying Neuroscience. He has been in the Lloyd lab for a year and a half and is very happy he chose to work here. His current focus is the p150-Glued gene, and mutations to this gene that are implicated in ALS, CMT, and HMN7. On campus, Dominick is a Training Officer and EMT on the Hopkins Emergency Response Unit, an active volunteer in Thread Mentorship Program, and a member of the JHU chapter of Nu Rho Psi. Dominick is from Long Island, NY, and in his free time enjoys working out, playing basketball, surfing, snowboarding, and playing card games and video games with his friends.

In Collaboration With:

Dr. Mark Wu, MD, PhD

Dr. Charlotte Sumner

Dr. Jeffrey Rothstein