Selected Publications

1. Cunningham KM, Maulding K, Ruan K, Senturk M, Grima JC, Sung H, Zuo Z, Song H, Gao J, Dubey S, Rothstein JD, Zhang K, Bellen HJ, Lloyd TE*. TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS. Elife. 2020 Dec 10;9:e59419. doi: 10.7554/eLife.59419. PMID: 33300868.
2. Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE*. TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2. Nat Commun. 2020 May 29;11(1):2679. doi: 10.1038/s41467-020-16411-5. PMID: 32471994; PMCID: PMC7260201.
3. Britson KA, Black AD, Wagner KR, Lloyd TE. Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice. J Vis Exp. 2019 Sep 16;(151). doi: 10.3791/59966.
4. Vogler TO*, Wheeler JR*, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB*, Parker R*. Amyloid-like TDP-43 myo-granules associate with 1 sarcomeric RNAs during skeletal muscle formation. Nature. 2018 Nov; 563(7732):508-513.
5. Zhang K, Daigle J.G., Cunningham KM, Grima JC, Gitler AD, Taylor JP, Rothstein, JD*, Lloyd TE*. Stress granule assembly disrupts nucleocytoplasmic transport. Cell 2018; 173(4):958-971
6. Lloyd TE, IP Fernandez, EH Michelle, L Christopher-Stine, K Pak, N Sacktor, and AL Mammen. Neurology. Overlapping features of polymyositis and inclusion body myositis in HIV-infected patients. 2017 Apr 11;88(15):1454-1460.
7. Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova Ol, Troncoso JC, Duan W, Matunis MJ, Ranum LP, Thompson LM, Lloyd TE, Ross CA, Rothstein JD. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron. 2017; Apr 5. 94(1):93-107.
8. Zhang K*, Donnelly CJ*, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE*, Rothstein JD* (2015) The C9ORF72 repeat expansion disrupts nucleocytoplasmic transport. Nature.
9. Wong CO, Lin YQ, Chen K, Chao Y, Duraine L, Lu Z, Yoon WH, Sullivan JM, Broadhead GT, Sumner CJ, Lloyd TE, Macleod GT, Bellen HJ, Venkatachalam K (2014) A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission. Neuron; 84(4):764-77.
10. Herrmann DN, Horvath R, Sowden JE, Gonzales M, Sanchez-Mejias A, Guan Z, Whittaker RG, Almodovar JL, Lane M, Bansagi B, Pyle A, Boczonadi V, Lochmüller H, Griffin H, Chinnery PF, Lloyd TE, Littleton JT, and Zuchner S (2014) Synaptotagmin 2 Mutations Cause Autosomal-Dominant Form of Lambert-Eaton Myasthenic Syndrome and Nonprogressive Motor Neuropathy The American Journal of Human Genetics; 95(3):332-9.
11. Machamer JB, Collins SE, Lloyd TE (2014) The ALS gene FUS regulates synaptic transmission at the Drosophila neuromuscular junction Human Molecular Genetics; 23(14)3810-22.
12. Liu S, Lamaze A, Liu W, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh A, Wu MN (2014) WIDE AWAKE Mediates the Circadian Timing of Sleep Onset Neuron; 82(1):151-66.
13. Xu D, Shen W, Guo R, Xue Y, Peng W, Sima J, Yang J, Sharov A, Srikantan S, Yang J, Fox D, Qian Y, Martindale JL, Piao Y, Machamer J, Joshi SR, Mohanty S, Shaw AC, Lloyd TE, Brown GW, Ko MSH, Gorospe M, Zou S, Wang W (2013) Top3β is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation. Nature Neuroscience; 16(9): 1238-47.
14. Lloyd TE, Machamer J, O’Hara K, Kim JH, Collins SE, Wong MY, Sahin B, Imlach W, Yang Y, Levitan ES, McCabe BD, Kolodkin AL. (2012) The p150Glued CAP-Gly Domain Regulates Initiation of Retrograde Transport at Synaptic Termini. Neuron. 2012; 74, 344-360.
15. Wong MY, Zhou C, Shakiryanova D, Lloyd TE, Deitcher DL, and Levitan ES. (2012) Neuropeptide Delivery to Synapses by Long Range Vesicle Circulation and Sporadic Capture. Cell. 148(5): 1029-38.
16. Lanson NA, Maltare A, King H, Smith R, Kim JH, Taylor JP, Lloyd TE, Pandey UB. (2010) A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. Human Molecular Genetics; 20:2510-2523.
17. Lloyd TE, Atkinson RA, Wu MN, Zhou Y, Pennetta G, Bellen HJ. (2002) Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila. Cell. 108: 261-269.
18. Verstreken P, Kjaerulff O, Lloyd TE, Atkinson R, Zhou Y, Meinerzhagen IA, Bellen HJ. (2002) Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell. 109: 101-12.
19. Lloyd TE, Verstreken P, Ostrin EJ, Phillippi A, Lichtarge O, Bellen HJ (2000) A Genome-wide Search for Synaptic Vesicle Cycle Proteins in Drosophila. Neuron. 26: 45-50.
21. ***Co-Authors from the Lloyd Lab are underlined and respective journals published in are displayed in bold text.***